The familiar's tears do not reset the multiplier if they miss, either.
Fetus: The damage multiplier that was gained before picking up this item will now be a permanent damage up. Cricket's Body/ The Parasite: Split tears that do not hit enemies are considered misses, nearly guaranteeing the chance of losing the multiplier.Brimstone: The damage multiplier that was gained before picking up this item will now be a permanent damage up.However, the spread shot granted by The Inner Eye and Mutant Spider may make it hard to retain the damage multiplier. 20/20/ The Inner Eye/ Mutant Spider/ Cursed Eye: If all tears hit, they all contribute to the damage multiplier.Tiny Planet: Isaac's tears no longer hit walls and stay in the air for longer, allowing many damage-amplified tears to be fired before the damage boost is lost.Rubber Cement The bonus cannot be lost since tears cannot run out of range.Additionally, if the tear fades out of existence instead of running out of range, it does not count as a miss. Proptosis: Tears are larger and easier to hit with at a low range.Pop!: Tears that miss an enemy and do not hit a wall or obstacle will not fall to the ground immediately, allowing many damage-amplified tears to be fired before the damage boost is lost.Petrification/ Slow items: Enemies will be petrified or slowed, making them easier to hit without missing.Since the controllable tear never hits the ground or wall, the bonus cannot be lost. The Ludovico Technique: Damage bonus increases until it hits the max of 2x.Dark Arts: Hitting enemies/bullets successfully with Dark Arts contributes to Dead Eye's damage multiplier.The burst tears never reset the multiplier. Lachryphagy Firing into the floating tear won't reset the multiplier unless it hits a wall.Compound Fracture/ Haemolacria/ Lachryphagy: Main tears and burst tears will contribute to damage multiplier.Due to the natural Brimstone effect of Azazel, he gains no benefit by picking up Deadeye unless his tear effect has been replaced.Because there are no walls or floors for tears to collide with in the fight with The Beast, the damage boost will not fade away.If Isaac is shooting multiple tears at once, like with Mutant Spider, only one of them has to land for the multiplier to build up.Tears do not have to be landed on only one enemy to build the multiplier as long as they do not miss, Isaac gains damage.If Dead Eye is removed by re-rolling it with D4, D100, or a 1 or 6 pip Dice Room, the damage multiplier will be removed, but the tears will continue to glow red.Shooting Hosts will increase the damage multiplier even if their skull is lowered down.Because blue fires do not deteriorate when shot at with tears, maximum damage can always be achieved as long as the fire is not destroyed by an explosion.This can be used to preemptively increase damage before entering a new room. Shooting Fire Places, Wall Huggers, and Stone Grimaces will count towards the multiplier. The effect is triggered by many entities aside from enemies.As the multiplier increases, Isaac's tears glow red and increase in size.The chance is 20% for the first miss, 33% for the second miss, and 50% for the third miss and beyond.
If a tear misses and hits nothing (wall/floor), there is a chance for the multiplier to be reset back to 1.The multiplier increases by 0.25x for each hit, going up to a maximum of 2x after 4 successive hits.Isaac's damage increases for each successive tear hit on enemies.